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49ers vs. Bills: Betting Preview, Odds, Predictions, and Picks

49ers Aim to Bounce Back Against Bills in Anticipated Matchup

On Sunday, the San Francisco 49ers will take on the Buffalo Bills in a pivotal Week 13 clash in the Northeast. With consecutive losses to the Seahawks and Packers, the 49ers are determined to rejuvenate their season, currently sitting at a 5-6 record—yet still in the playoff hunt, just one game behind in the competitive NFC West. Conversely, the Bills are on an impressive streak, recently defeating the Chiefs and eyeing the top spot in the AFC with a record of 7-4.

San Francisco’s offensive struggles have been notable, particularly for star running back Christian McCaffrey, who has averaged only 3.5 yards per carry since returning from an Achilles injury. Quarterback Brock Purdy’s performance has also been underwhelming, with 13 touchdowns to eight interceptions, contributing to uncertainties about his availability this Sunday.

The odds favor Buffalo as they emerge as seven-point home favorites, boasting a robust defense and the ability to score heavily—having surpassed 30 points in five consecutive games. Although both teams have been inconsistent against the spread, the Bills have performed well recently, making this a crucial game for San Francisco, which needs a win to maintain its playoff aspirations.

As excitement builds for this showdown, expectations are high. Analysts predict it will be a challenging match for the 49ers, especially with McCaffrey’s situation and Purdy’s unclear status.

With the stakes high for both teams—Buffalo aiming to secure a playoff spot and the 49ers desperate to snap their losing streak—fans can expect a thrilling encounter on Sunday.

Predicted Outcome: Bills to continue their dominance with a projected victory, keeping the 49ers on their toes.

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Photo credit www.pennlive.com

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